Marcia R. Cruz-Correa, MD, PhD

Marcia R. Cruz-Correa, MD, PhD

Marcia R. Cruz-Correa, MD, PhD
Associate Professor of Medicine
787-772-8300 ext. 1221
Biochemistry and Surgery
Principal Investigator – UPR/MDACC

Dr. Cruz-Correa leads a Gastrointestinal Oncology Program at the UPR Cancer Center, which is integrated by a multidisciplinary team of clinicians, basic and clinical scientists, and epidemiologists with an expertise in gastrointestinal cancer.  The main focus of the Program is to elucidate genetic and epigenetic pathways for colorectal carcinogenesis among Hispanic patients.  Evaluation of environmental and nutritional factors as effect-modifiers and gene-environmental interactions is an active investigative priority. Dr. Cruz-Correa and her team developed the first population-based familial colorectal cancer registry in Puerto Rico that currently has over 500 colorectal cancer patients with detailed epidemiological and environmental information (  A second research area is chemoprevention, and Dr. Cruz-Correa leads an NCI sponsored clinical trial evaluating the role of bioflavinoids (curcumin) as a chemopreventive agent in adult patients with Familial Adenomatous polyposis (FAP) and is a co-investigator evaluating the use of celecoxib in pediatric patients with FAP.  In addition, her group is a member of the Polyp Prevention Study Group (11-site national consortia, lead by Dr. John Baron, Dartmouth University) participating in several clinical trials aimed at evaluating different compounds for chemoprevention of sporadic colorectal adenomas.  Dr. Cruz-Correa’s research is sponsored by the National Cancer Institute and other private foundations including Doris Duke Charitable Foundation and the Cancer Research Prevention Foundation.



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1. Cruz-Correa M, Diaz-Algorri Y, Mendez V, Vazquez PJ, Lozada ME, Freyre K, Lathroum   L, Gonzalez-Pons M, Hernandez-Marrero J, Giardiello F, Rodriguez-Quilichini S. Clinical characterization and mutation spectrum in Hispanic families with adenomatous polyposis syndromes. Fam Cancer. 2013 Sep;12(3):555-62. [PMID 23460355]

2. Edelstein DL, Axilbund JE, Hylind LM, Romans K, Griffin CA, Cruz-Correa M, Giardiello FM.  Serrated polyposis: rapid and relentless development of colorectal neoplasia.Gut. 2013 Mar;62(3):404-8. [PMID: 22490521]

3. Acevedo A, Diaz Y, Perez C, Garau M, Baron J, Cruz-Correa M. Diabetes Mellitus and Colorectal Neoplasia.  J Cancer Ther. 2012 Nov 1;3(6A):859-865.[PMID 23560242]

4. Falk GW, Buttar NS, Foster NR, Ziegler KL, Demars CJ, Romero Y, Marcon NE, Schnell T, Corley DA, Sharma P, Cruz-Correa MR, Hur C, Fleischer DE, Chak A, Devault KR,         Weinberg DS, Della'Zanna G, Richmond E, Smyrk TC, Mandrekar SJ, Limburg PJ. A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. Gastroenterology. 2012 Oct;143(4):917-26. [PMID: 22796132]

5. González L, Ortiz AP, Suárez E, Umpierre S, Marcos MJ, Billoch J, Joy L, Charneco E, Lacourt MY, Bernabe-Dones RD, Cruz-Correa M.Case-case study of factors associated to hMLH1, hMSH2, and hMSH6 protein expression among endometrial cancer patients of the University Hospital of San Juan, Puerto Rico.  Int J Gynecol Cancer. 2012 Jun;22(5):826-9. [PMID: 22635031]

6. Lathroum L, Ramos-Mercado F, Hernandez-Marrero J, Villafaña M, Cruz-Correa M.  Ethnic and Sex Disparities in Colorectal Neoplasia Among Hispanic Patients Undergoing Screening Colonoscopy.  Clin Gastroenterol Hepatol. 2012 Apr 25. [PMID 22542749]

7. Edelstein DL, Axilbund JE, Hylind LM, Romans K, Griffin CA, Cruz-Correa M, Giardiello FM.  Serrated polyposis: rapid and relentless development of colorectal neoplasia.Gut. 2012 Apr 5. [PMID: 22490521]

8. Edelstein DL, Giardiello FM, Basiri A, Hylind LM, Romans K, Axilbund JE, Cruz-Correa M, Ramella-Roman JC.  A new phenotypic manifestation of familial adenomatous polyposis.Fam Cancer. 2011 Jun;10(2):309-13. [PMID: 21547505].

9. Edelstein DL, Axilbund J, Baxter M, Hylind LM, Romans K, Griffin CA, Cruz-Correa M, Giardiello FM. Rapid Development of Colorectal Neoplasia in Patients With Lynch Syndrome. Clin Gastroenterolo Hepatol 2011 Apr;9(4):340-3 [PMID: 21070872]

10. Zuo QS, Yan R, Feng DX, Zhao R, Chen C, Jiang YM, Cruz-Correa M, Casson AG, Kang XD, Han F, Chen T.Loss of imprinting and abnormal expression of the insulin-like growth factor 2 gene in gastric cancer. Mol Carcinog. 2011 Jan 25. [PMID: 21268128]